ABSTRACT
Objective To research the clinical value of cerebrospinal fluid and peripheral blood tuberculosis infection T cell spot test(TSPOT .TB) in the diagnosis of tuberculous meningitis(TBM) .Methods 35 cases of TBM and 40 cases of non-TB intracranial infection in this hospital from September 2015 to September 2016 were selected as the observation group and control group respectively .T-SPOT .TB was adopted to detect mycobacterium tuberculosis effector T cells in cerebrospinal fluid and detect peripheral blood mononuclear cells .Results The T-SPOT .TB detection positive rates of cerebrospinal fluid and peripheral blood in the observation group were 97 .14% and 80 .00% respectively ,which were significantly higher than 2 .50% and 0 .00% in the control group ,the difference was statistically significant(P＜ 0 .05);the sensitivity and negative predictive value in cerebrospinal fluid T-SPOT .TB detection were 97 .14% and 97 .50% ,which were significantly higher than 80 .00% and 85 .11% in peripheral blood T-SPOT .TB detection ,the difference was statistically significant (P＜0 .05);the specificity and positive predictive value in the cerebrospinal fluid T-SPOT .TB detection was 97 .50% and 97 .14% respectively ,while which in peripheral blood T-SPOT .TB detection were 100 .00% and 100 .00% respectively ,but the difference between the two groups was not statistically significant ( P＞0 .05) .Conclusion The detection of cerebrospinal fluid and peripheral blood T-SPOT .TB detection can provide early diagnostic basis for TBM ,moreover cerebrospinal fluid T-SPOT .TB detection has higher sensitivity and possesses an important clinical application value .